Curcumin prevents tenofovir/lamivudine/efavirenzinduced nephrotoxicity in rats

Background and Aims: Nephrotoxicity is an adverse effect, which may occur with the use of tenofovir/lamivudine/efavirenz (TLE) in treatment human immune deficiency virus (HIV) infection. Curcumin (CUM), isolate Curcuma longa L. used folk medicine for ailments. This study attempts to establish whether CUM supplementation can protect against a rat model TLE-induced nephrotoxicity. Materials Methods: Adult male Wistar rats (n=40) were randomly grouped supplemented orally (50, 100 200 mg/kg/day) prior oral administration TLE (300/300/600 30 days. After treatment, fasted overnight, weighed anesthetized. Blood samples collected, sera extracted biochemical analyses. Kidney excised, processed oxidative stress markers histology. Results: Body weight was decreased (p<0.01) whereas kidney increased administered when compared control. Significant (p<0.001) increments serum uric acid, creatinine, urea malondialdehyde levels observed TLE-administered rats. decreases total protein, albumin, electrolytes, superoxide dismutase, glutathione, catalase glutathione peroxidase produced tubular necrosis hypercellular glomerulus mesangial proliferation kidneys treated However, mg/kg) abrogates nephrotoxicity dose-related manner at p<0.05, p<0.01 p<0.001, respectively, group. Conclusion: seems effective